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Updated: Feb 10, 2026
15:49
Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System
Published on: October 16, 2013
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Microscopic colitis: a population-based case series over a 9-year period in Northern Ireland
M Moore1, H G Coleman2, P B Allen3
1Department of Cellular Pathology, Royal Victoria Hospital, Belfast Health and Social Care Trust, Belfast, UK.
Summary
Microscopic colitis (MC), including collagenous colitis (CC) and lymphocytic colitis (LC), is a benign condition. Most cases respond well to treatment, and left colon sampling during flexible sigmoidoscopy diagnoses most cases.
Area of Science:
- Gastroenterology
- Pathology
- Epidemiology
Background:
- Microscopic colitis (MC) encompasses collagenous colitis (CC) and lymphocytic colitis (LC).
- Understanding the clinicopathological features and incidence of MC is crucial for patient management.
Purpose of the Study:
- To report the clinicopathological experience of microscopic colitis in a population-based case series.
- To determine the incidence and characteristics of CC and LC in Northern Ireland.
Main Methods:
- A 9-year population-based case series (2008-2016) in Northern Ireland.
- Interrogation of a pathology laboratory information system for CC and LC diagnoses.
- Collection of demographic, clinical, and follow-up data from healthcare records.
Main Results:
- 326 new MC diagnoses identified, with an average annual incidence of 6.7 per 100,000.
- CC and LC predominantly affected women aged 60-79.
- 15% showed endoscopic abnormalities; most cases responded to treatment, with low rates of persistent disease.
Conclusions:
- CC and LC are benign conditions with similar demographics, clinical associations, management, and outcomes.
- Left colonic sampling during flexible sigmoidoscopy diagnoses the majority of MC cases.
- Separate sampling of right and left colon is advised when MC is suspected.
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