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Drug Delivery: Overview01:16

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
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The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
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Updated: Feb 10, 2026

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
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Fast Degradable Polycaprolactone for Drug Delivery.

Seo Hee Chang1, Hyun Jung Lee1, Sohee Park1

  • 1Department of Chemistry and Nanoscience , Ewha Womans University , 52 Ewhayeodae-gil , Seodaemun-gu, Seoul , 03760 , Korea.

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Researchers developed oxalate-connected oligocaprolactone (PCL-OX) multiblock copolymers, a fast-degrading PCL alternative to poly(lactide-co-glycolide) (PLGA). PCL-OX microspheres demonstrate comparable in vivo drug delivery and tissue compatibility to PLGA.

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Drug Delivery Systems

Background:

  • Polycaprolactone (PCL) has limited biomedical use due to slow degradation.
  • Poly(lactide-co-glycolide) (PLGA) is widely used but has different degradation characteristics.
  • A need exists for PCL-based materials with tunable degradation rates.

Purpose of the Study:

  • To develop a fast-degrading PCL-based biomaterial.
  • To evaluate the in vivo performance of oxalate-connected oligocaprolactone (PCL-OX) multiblock copolymers.
  • To compare PCL-OX with PLGA for drug delivery and biocompatibility.

Main Methods:

  • Synthesis of oxalate-connected oligocaprolactone multiblock copolymers (PCL-OX).
  • Fabrication of paclitaxel-loaded PCL-OX and PLGA microspheres.
  • In vivo evaluation of drug release kinetics and plasma concentration over 28 days.
  • Assessment of microsphere degradation and tissue compatibility via subcutaneous implantation in rats.

Main Results:

  • PCL-OX maintained PCL's crystalline properties and low melting point while exhibiting faster degradation.
  • Paclitaxel-loaded PCL-OX microspheres achieved steady plasma drug concentrations (6-9 μg/mL) over 28 days, similar to PLGA.
  • Both PCL-OX and PLGA microspheres were fully cleared within two months post-implantation.
  • PCL-OX microspheres demonstrated comparable subcutaneous tissue compatibility to PLGA microspheres.

Conclusions:

  • PCL-OX is a promising fast-degrading PCL biomaterial.
  • PCL-OX offers a viable alternative to PLGA for biomedical applications requiring controlled degradation.
  • The developed PCL-OX copolymers address the limitations of traditional PCL.