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Updated: Feb 10, 2026

Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells
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CXCL12/CXCR4 Signaling Enhances Human PSC-Derived Hematopoietic Progenitor Function and Overcomes Early In Vivo

Jennifer C Reid1, Borko Tanasijevic2, Diana Golubeva1

  • 1Stem Cell and Cancer Research Institute, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON L8N 3Z5, Canada; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8N 3Z5, Canada.

Stem Cell Reports
|May 10, 2018
PubMed
Summary

Human pluripotent stem cells (hPSCs) can generate hematopoietic progenitor cells (HPCs), but they fail to engraft. Enhancing CXCR4 expression improved HPC survival and function in vivo, but not long-term hematopoietic stem cell (HSC) reconstitution.

Keywords:
bone marrowcell signalingchemokine receptorhematopoietic stem cellshuman pluripotentprogenitorstransplantation

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