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Updated: Feb 10, 2026

Acute Mouse Brain Slicing to Investigate Spontaneous Hippocampal Network Activity
Published on: August 28, 2020
Hippocampal Network Dynamics during Rearing Episodes
Albert M Barth1, Andor Domonkos1, Antonio Fernandez-Ruiz2
1Cerebral Cortex Research Group, Department of Cell and Network Neurobiology, Institute of Experimental Medicine of the Hungarian Academy of Sciences, Budapest 1083, Hungary.
Abstract:
Animals build a model of their surroundings on the basis of information gathered during exploration. Rearing on the hindlimbs changes the vantage point of the animal, increasing the sampled area of the environment. This environmental knowledge is suggested to be integrated into a cognitive map stored by the hippocampus. Previous studies have found that damage to the hippocampus impairs rearing. Here, we characterize the operational state of the hippocampus during rearing episodes. We observe an increase of theta frequency paralleled by a sink in the dentate gyrus and a prominent theta-modulated fast gamma transient in the middle molecular layer. On the descending phase of rearing, a decrease of theta power is detected. Place cells stop firing during rearing, while a different subset of putative pyramidal cells is activated. Our results suggest that the hippocampus switches to a different operational state during rearing, possibly to update spatial representation with information from distant sources.
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