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Direct Mouse Trauma/Burn Model of Heterotopic Ossification
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Heterotopic Ossification Formation Following a Simple Concussion: A Case Report
Patrick K O'Callaghan1, Elliott Carter, Zeke Walton
1Departments of Orthopaedics (P.K.O'C. and Z.W.), Radiology (R.C.), and Pathology and Laboratory Medicine (E.B.), Medical University of South Carolina (E.C.), Charleston, South Carolina.
JBJS Case Connector
|May 10, 2018
Summary
Heterotopic ossification (HO) is bone formation in soft tissues, typically after brain injury. This case report details a rare instance of HO in a young woman linked solely to a concussion, with no other known risk factors.
Area of Science:
- Orthopedic Surgery
- Neurology
- Pathology
Background:
- Heterotopic ossification (HO) involves abnormal bone development in soft tissues.
- HO is a known complication following traumatic brain injury (TBI).
- Risk factors for HO include TBI, burns, and certain genetic conditions.
Observation:
- A 19-year-old woman presented with a 3-month history of a progressively enlarging mass on her proximal femur.
- Imaging and biopsy confirmed the mass as heterotopic ossification.
- The patient's only reported risk factor was a history of concussion.
Findings:
- Surgical resection of the heterotopic ossification was performed.
- The patient experienced no recurrence of the lesion at the 12-month follow-up.
- This case represents a unique presentation of HO solely associated with a concussion.
Implications:
- This case expands the understanding of potential triggers for heterotopic ossification.
- It highlights the importance of considering concussion as a potential risk factor for HO, even in the absence of other known causes.
- Further research may be warranted to explore the specific mechanisms linking concussion to HO.
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