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Updated: Feb 10, 2026

Direct Mouse Trauma/Burn Model of Heterotopic Ossification
Published on: August 6, 2015
Heterotopic Ossification Formation Following a Simple Concussion: A Case Report
Patrick K O'Callaghan1, Elliott Carter, Zeke Walton
1Departments of Orthopaedics (P.K.O'C. and Z.W.), Radiology (R.C.), and Pathology and Laboratory Medicine (E.B.), Medical University of South Carolina (E.C.), Charleston, South Carolina.
Case:
A 19-year-old woman presented with a 3-month history of an enlarging lesion on the proximal aspect of the femur. After imaging studies and a biopsy had been performed, the mass was determined to represent heterotopic ossification (HO). The only known risk factor was a history of concussion. The mass was resected and, as of the 12-month follow-up, had not recurred.
Conclusion:
HO is a potentially serious complication of ossification in soft tissues that can develop secondary to several disease states; it commonly occurs following traumatic brain injury. To our knowledge, this is the only case report that describes HO associated with a concussion and no other risk factors.
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