Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genetic Screens02:46

Genetic Screens

5.8K
Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
5.8K
The Evidence for Evolution02:55

The Evidence for Evolution

48.4K
Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.
48.4K
Convergent Evolution01:54

Convergent Evolution

33.1K
Evolution shapes the features of organisms over time, ensuring that they are suited for the environments in which they live. Sometimes, selection pressure leads to the rise of similar but unrelated adaptations in organisms with no recent common ancestors, a process known as convergent evolution.
33.1K
What is Population Genetics?01:25

What is Population Genetics?

64.9K
A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
64.9K
Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

9.3K
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
9.3K
Eukaryotic Evolution01:24

Eukaryotic Evolution

42.3K
The endosymbiont theory is the most widely accepted theory of eukaryotic evolution; however, its progression is still somewhat debated. According to the nucleus-first hypothesis, the ancestral prokaryote first evolved a membrane to enclose DNA and form the nucleus. Conversely, the mitochondria-first hypothesis suggests that the nucleus was formed after endosymbiosis of mitochondria.
Contrary to the endosymbiont theory, the eukaryote-first hypothesis proposes that the simpler prokaryotic and...
42.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chronic suppression of a multidrug-resistant Pseudomonas aeruginosa in prosthetic joint infection using personalized bacteriophage treatment.

Nature communications·2026
Same author

<i>Pseudomonas aeruginosa</i> biofilm-deficient mutants undergo parallel evolution during chronic infection.

Journal of bacteriology·2026
Same author

Genetic diversification of <i>Pseudomonas fluorescens</i> maintained by multi-niche selection within biofilms.

Applied and environmental microbiology·2026
Same author

Methods for cost-efficient, whole genome sequencing surveillance for enhanced detection of outbreaks in a hospital setting.

medRxiv : the preprint server for health sciences·2025
Same author

<i>Pseudomonas aeruginosa</i> biofilm-deficient mutants undergo parallel adaptation during chronic infection.

bioRxiv : the preprint server for biology·2025
Same author

Microbes without borders: uniting societies for climate action.

mBio·2025
Same journal

Salinity-driven microbial adaptation of hydrocarbon-degrading communities in coastal sediments.

mSphere·2026
Same journal

Tools for genetic manipulation of the endemic fungal pathogen <i>Emergomyces africanus</i> and application of a fluorescent reporter strain in infection models.

mSphere·2026
Same journal

Cysteine-S-nitrosylation inhibits ROP5-mediated immune evasion in <i>Toxoplasma gondii</i>.

mSphere·2026
Same journal

Inheritance of four-membrane-bound structures in the "apicoplast-minus" <i>Plasmodium falciparum</i>.

mSphere·2026
Same journal

mSphere of Influence: The bacterial growth law-revisiting the old to discover the new.

mSphere·2026
Same journal

Preclinical characterization of immune responses induced by a candidate gonococcal native outer membrane vesicle vaccine.

mSphere·2026
See all related articles

Related Experiment Video

Updated: Feb 10, 2026

Author Spotlight: Understanding Microbe Adaptation Using Innovative Techniques for Exploring Thermophilic Evolution
08:11

Author Spotlight: Understanding Microbe Adaptation Using Innovative Techniques for Exploring Thermophilic Evolution

Published on: June 14, 2024

1.4K

Experimental Evolution as a High-Throughput Screen for Genetic Adaptations.

Vaughn S Cooper1,2

  • 1Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA vaughn.cooper@pitt.edu.

Msphere
|May 11, 2018
PubMed
Summary
This summary is machine-generated.

Experimental evolution uses controlled conditions to study evolutionary processes. Selection typically dominates, making rapid mutants strong candidates for identifying adaptive traits and fitness-increasing mutations.

Keywords:
evolutionary biologygenomicspopulation genetics

More Related Videos

Multi-enzyme Screening Using a High-throughput Genetic Enzyme Screening System
08:10

Multi-enzyme Screening Using a High-throughput Genetic Enzyme Screening System

Published on: August 8, 2016

9.3K
High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes
09:44

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes

Published on: March 3, 2015

10.0K

Related Experiment Videos

Last Updated: Feb 10, 2026

Author Spotlight: Understanding Microbe Adaptation Using Innovative Techniques for Exploring Thermophilic Evolution
08:11

Author Spotlight: Understanding Microbe Adaptation Using Innovative Techniques for Exploring Thermophilic Evolution

Published on: June 14, 2024

1.4K
Multi-enzyme Screening Using a High-throughput Genetic Enzyme Screening System
08:10

Multi-enzyme Screening Using a High-throughput Genetic Enzyme Screening System

Published on: August 8, 2016

9.3K
High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes
09:44

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes

Published on: March 3, 2015

10.0K

Area of Science:

  • Evolutionary Biology
  • Microbial Genetics
  • Population Genetics

Background:

  • Experimental evolution propagates organisms under controlled conditions to study evolution.
  • Population genetic forces like selection, mutation, drift, and recombination influence evolving populations.
  • The relative impact of these forces can be complex and difficult to ascertain.

Purpose of the Study:

  • To explain why experimental evolution outcomes can be viewed with greater certainty.
  • To highlight the dominant role of selection in experimental evolution.
  • To present the evolve-and-resequence approach as a powerful tool for identifying adaptive mutations.

Main Methods:

  • Founding populations from known genotypes.
  • Propagating populations under controlled selective environments.
  • Utilizing whole-genome sequencing of high-frequency mutants (evolve-and-resequence).

Main Results:

  • Selection is typically the dominant force in experimental evolution.
  • Mutants rapidly increasing in frequency possess adaptive traits.
  • Genome sequencing identifies genes and pathways conferring adaptation and increased fitness.

Conclusions:

  • Experimental evolution, particularly the evolve-and-resequence method, reliably identifies adaptive mutations.
  • Understanding selection's dominance provides certainty in interpreting evolutionary outcomes.
  • This approach is effective for discovering genetic bases of adaptation in new environments.