Related Experiment Video
Updated: Feb 10, 2026

Measurements of CO2 Fluxes at Non-Ideal Eddy Covariance Sites
Published on: June 24, 2019
Thermodynamic constraints for identifying elementary flux modes
Sabine Peres1,2, Stefan Schuster3, Philippe Dague4,4
1LRI, Université Paris-Sud, CNRS, Université Paris-Saclay, 91405 Orsay, France speres@lri.fr.
Abstract:
Metabolic pathway analysis is a key method to study metabolism and the elementary flux modes (EFMs) is one major concept allowing one to analyze the network in terms of minimal pathways. Their practical use has been hampered by the combinatorial explosion of their number in large systems. The EFMs give the possible pathways at steady state, but the real pathways are limited by biological constraints. In this review, we display three different methods that integrate thermodynamic constraints in terms of Gibbs free energy in the EFMs computation.
Related Concept Videos
Third Law of Thermodynamics
Second Law of Thermodynamics
Second Law of Thermodynamics
First Law of Thermodynamics
First Law of Thermodynamics
Constraints and Statical Determinacy

