Alternative Patterning Methods for Paper-based Analytical Devices Using Nail Polish as a Hydrophobic Reagent.

Area of Science:

• Materials Science
• Analytical Chemistry
• Chemical Engineering

Background:

• Paper-based analytical devices (PADs) offer low-cost diagnostics.
• Existing fabrication methods can be complex and expensive.
• Need for accessible and robust PAD fabrication techniques.

Purpose of the Study:

• To develop a rapid, easy, and cost-effective fabrication method for PADs.
• To evaluate nail polish as a hydrophobic reagent for PADs.
• To compare writing, stamping, and spraying fabrication approaches.

Main Methods:

• Investigated three fabrication methods: writing, stamping, and spraying using nail polish.
• Utilized laser-cut masks for stamping and spraying techniques.
• Assessed the solvent resistance of nail polish-treated PADs against basic and organic solutions.

Main Results:

• All three methods (writing, stamping, spraying) were cost-effective and required no extra equipment.
• The spraying method proved most suitable for mass production with the best resolution.
• Nail polish-treated PADs demonstrated resistance to strong basic solutions and organic solvents, showing potential as organic-aqueous separators.

Conclusions:

• Nail polish is a viable, low-cost hydrophobic material for PAD fabrication.
• The spraying method offers scalability and precision for PAD manufacturing.
• Nail polish-treated PADs have potential applications in separation and diagnostics.