Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

33.9K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.9K
Epigenetic Regulation01:37

Epigenetic Regulation

3.9K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.9K
Forced Transdifferentiation01:28

Forced Transdifferentiation

2.4K
Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial...
2.4K
Oscillations In An LC Circuit01:30

Oscillations In An LC Circuit

3.2K
An idealized LC circuit of zero resistance can oscillate without any source of emf by shifting the energy stored in the circuit between the electric and magnetic fields. In such an LC circuit, if the capacitor contains a charge q before the switch is closed, then all the energy of the circuit is initially stored in the electric field of the capacitor. This energy is given by
3.2K
Forced Oscillations01:06

Forced Oscillations

8.0K
When an oscillator is forced with a periodic driving force, the motion may seem chaotic. The motions of such oscillators are known as transients. After the transients die out, the oscillator reaches a steady state, where the motion is periodic, and the displacement is determined.
8.0K
Damped Oscillations01:07

Damped Oscillations

7.3K
In the real world, oscillations seldom follow true simple harmonic motion. A system that continues its motion indefinitely without losing its amplitude is termed undamped. However, friction of some sort usually dampens the motion, so it fades away or needs more force to continue. For example, a guitar string stops oscillating a few seconds after being plucked. Similarly, one must continually push a swing to keep a child swinging on a playground.
Although friction and other non-conservative...
7.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dynamics of Marangoni-driven elliptical Janus particles.

Soft matter·2026
Same author

Compaction of chromatin domains regulates target search times of proteins.

PLoS computational biology·2026
Same author

Emergent stable tissue shapes from the regulatory feedback between morphogens and cell growth.

Journal of theoretical biology·2025
Same author

The Role of Lamins in Genome Organisation: A Modelling Perspective.

Sub-cellular biochemistry·2025
Same author

Liquid-liquid phase separation of lamin drives altered chromatin organization in cardiomyopathic mutations of lamin A.

Nucleic acids research·2025
Same author

Structural, Magnetic, and Optical Properties of Sol-Gel Synthesized Fe-Doped NiO Nanoparticles with Tunable Fluorescence Toward Acridine Orange.

Chemphyschem : a European journal of chemical physics and physical chemistry·2025

Related Experiment Video

Updated: Feb 10, 2026

Generation of Myospheres From hESCs by Epigenetic Reprogramming
09:32

Generation of Myospheres From hESCs by Epigenetic Reprogramming

Published on: June 21, 2014

8.3K

Reprogramming, oscillations and transdifferentiation in epigenetic landscapes.

Bivash Kaity1, Ratan Sarkar2, Buddhapriya Chakrabarti3

  • 1IIT Bombay, Department of Physics, Mumbai, 400076, India.

Scientific Reports
|May 11, 2018
PubMed
Summary

This study reveals how time delays in gene networks influence cell differentiation. It establishes a theoretical basis for transdifferentiation, enabling cell type transitions without reverting to an undifferentiated state.

More Related Videos

ATAC-Seq Optimization for Cancer Epigenetics Research
07:13

ATAC-Seq Optimization for Cancer Epigenetics Research

Published on: June 30, 2022

5.4K
An R-Based Landscape Validation of a Competing Risk Model
05:37

An R-Based Landscape Validation of a Competing Risk Model

Published on: September 16, 2022

2.6K

Related Experiment Videos

Last Updated: Feb 10, 2026

Generation of Myospheres From hESCs by Epigenetic Reprogramming
09:32

Generation of Myospheres From hESCs by Epigenetic Reprogramming

Published on: June 21, 2014

8.3K
ATAC-Seq Optimization for Cancer Epigenetics Research
07:13

ATAC-Seq Optimization for Cancer Epigenetics Research

Published on: June 30, 2022

5.4K
An R-Based Landscape Validation of a Competing Risk Model
05:37

An R-Based Landscape Validation of a Competing Risk Model

Published on: September 16, 2022

2.6K

Area of Science:

  • Systems Biology
  • Developmental Biology
  • Computational Biology

Background:

  • Waddington's epigenetic landscape models cell differentiation pathways.
  • Quantifying these landscapes using gene regulatory networks is an active research area.
  • Understanding reverse programming and cell fate transitions is crucial.

Purpose of the Study:

  • To investigate the impact of time delays on the cell differentiation landscape.
  • To explore the theoretical basis of transdifferentiation in gene regulatory networks.
  • To analyze the role of delayed feedback and chemical drives in cell fate determination.

Main Methods:

  • Mathematical modeling of a two-gene regulatory network.
  • Analysis of gene regulatory networks with self-promoting and mutually inhibiting genes.
  • Incorporation of time delays from multi-step reactions and epigenetic rearrangements.

Main Results:

  • Time delays significantly shape the cell differentiation landscape.
  • A theoretical framework for direct transdifferentiation between cell types is established.
  • Long-lived oscillatory states emerge due to delayed feedback and chemical drives.

Conclusions:

  • Time-delayed feedback loops are critical in gene regulatory circuits.
  • This work provides a framework for characterizing epigenetic landscapes.
  • The findings offer insights into cell plasticity and reprogramming.