Related Experiment Video
Updated: Feb 10, 2026
06:08
Apical Resection Mouse Model to Study Early Mammalian Heart Regeneration
Published on: January 23, 2016
11.9K
Cell therapy trials for heart regeneration - lessons learned and future directions
1Department of Cardiovascular Surgery, Université Paris Descartes, Sorbonne Paris Cité, INSERM U-970, Hôpital Européen Georges Pompidou, Paris, France. philippe.menasche@aphp.fr.
Nature Reviews. Cardiology
|May 11, 2018
Summary
Cell therapy shows promise for heart regeneration in chronic cardiomyopathy, but efficacy requires further study. Future trials should focus on remuscularization or activating host repair pathways for better outcomes.
Area of Science:
- Cardiovascular Medicine
- Regenerative Medicine
- Stem Cell Therapy
Background:
- Cell therapy is being investigated for heart regeneration in chronic cardiomyopathy.
- Clinical trials have used various cell types, including mesenchymal stem cells and cardiac-committed cells.
Purpose of the Study:
- To review outcomes of cell therapy trials for heart regeneration.
- To provide perspectives for future cell-based regenerative trials.
Main Methods:
- Categorization of trials based on cell type: noncardiac stem cells vs. cardiac-committed cells.
- Summary of main outcomes and lessons learned from completed studies.
Main Results:
- Cell therapy has demonstrated consistent safety in patients with chronic cardiomyopathy.
- The efficacy of cell therapies for heart regeneration remains elusive, requiring further investigation.
Conclusions:
- Future trials should optimize cell delivery, survival, and integration for remuscularization.
- Alternatively, focusing on activating endogenous repair pathways via paracrine signaling or secretome administration offers flexibility.
Related Concept Videos
01:21Stem Cell Therapy for Tissue Regeneration
4.7K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.7K
01:22Heart Failure VI: Adjunct Therapies
391
Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
391
01:27Anatomy of the Heart
120.1K
The human heart is made up of three layers of tissue that are surrounded by the pericardium, a membrane that protects and confines the heart. The outermost layer, closest to the pericardium, is the epicardium. The pericardial cavity separates the pericardium from the epicardium. Beneath the epicardium is the myocardium, the middle layer, and the endocardium, the innermost layer. There are four chambers of the heart: the right atrium, the right ventricle, the left atrium, and the left ventricle.
120.1K
01:12Trial and Error and Algorithm
429
A problem-solving strategy is a plan of action used to find a solution. Different strategies have distinct action plans. Trial and error involves trying different solutions until one works. For instance, to fix a broken printer, you might check ink levels, ensure the paper tray isn't jammed, and verify the printer's connection to your laptop. This method can be time-consuming but is commonly used. Thomas Edison, for example, used trial and error to find a suitable filament for the light...
429
01:11Clinical Trials: Overview
5.0K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
5.0K
01:16Clinical Trials
10.9K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
There are four phases in a clinical trial. A phase one...
10.9K