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EEG Mu Rhythm in Typical and Atypical Development
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A typical atypical chronic myeloid leukemia.

Andrea Gilioli1, Ambra Paolini1, Goretta Bonacorsi1

  • 1Section of Hematology Department of Medical and Surgical Sciences Azienda Ospedaliera Universitaria di Modena Università di Modena e Reggio Emilia Modena Italy.

Clinical Case Reports
|May 11, 2018
PubMed
Summary

Atypical chronic myeloid leukemia can be suspected in cases of leukocytosis with abnormal neutrophil development. Look for clumped chromatin in irregularly coarse nuclei for diagnosis.

Keywords:
aCMLclinical casehematologyleukocytosisperipheral blood smear

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Area of Science:

  • Hematology
  • Oncology
  • Cellular Biology

Background:

  • Leukocytosis, an elevation in white blood cells, can stem from various causes.
  • Distinguishing between different types of leukemia is crucial for effective treatment.

Observation:

  • The study focuses on specific morphological changes in neutrophils and their precursors.
  • Key features include significant dysgranulopoiesis and minimal basophilia or monocytosis.

Findings:

  • The presence of "clumped" chromatin within irregularly coarse, compacted nuclei is a significant diagnostic indicator.
  • This specific nuclear morphology is associated with atypical chronic myeloid leukemia.

Implications:

  • Identifying "clumped" chromatin aids in the early suspicion and diagnosis of atypical chronic myeloid leukemia.
  • This morphological clue can guide further diagnostic workup and patient management.