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Related Experiment Video

Updated: Feb 10, 2026

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

Calcific uremic arteriolopathy.

Olanrewaju A Olaoye¹, Abhilash Koratala¹

¹Division of Nephrology, Hypertension and Renal Transplantation, University of Florida, Gainesville, FL, USA.

Oxford Medical Case Reports

|May 11, 2018

Summary

This summary is machine-generated.

Calcific uremic arteriolopathy (CUA), a rare condition in dialysis patients, can affect the glans penis. This case highlights the severe outcomes, including sepsis and death, associated with CUA.

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Area of Science:

Nephrology
Dermatology
Pathology

Background:

Calcific uremic arteriolopathy (CUA), also known as calciphylaxis, is a devastating condition primarily affecting end-stage renal disease patients.
It is characterized by medial calcification of dermal arterioles, leading to vascular thrombosis, ischemic necrosis, and high mortality rates, often due to sepsis.

Observation:

This report details a rare case of CUA affecting the glans penis in a uremic patient.
The patient presented with symptoms indicative of CUA in this unusual location.

Findings:

Histologic examination would reveal the characteristic medial calcification of arterioles, thrombosis, and ischemic necrosis.
The clinical presentation in this case, despite the atypical location, aligns with established CUA pathology.

Implications:

This case underscores the potential for CUA to manifest in diverse anatomical sites, even the glans penis.
It emphasizes the critical need for early recognition and management of CUA to mitigate the risk of severe complications like sepsis and mortality in uremic patients.