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An in vivo study on the effect of coating stability on osteointegration performance of collagen/hyaluronic acid
Haiyong Ao1,2, Jiajia Zong1, Yanjiao Nie1
1School of Materials Science and Engineering, East China Jiaotong University, Nanchang, 330013, China.
Abstract:
Aseptic loosening of implant is one of the main causes of Ti-based implant failure. In our previous work, a novel stable collagen/hyaluronic acid (Col/HA) multilayer modified titanium coatings (TCs) was developed by layer-by-layer (LBL) covalent immobilization technique, which showed enhanced biological properties compared with TCs that were physically absorbed with Col/HA multilayer in vitro. In this study, a rabbit model with femur condyle defect was employed to compare the osteointegration performance of them. Results indicated that Col/HA multilayer with favourable stability could better facilitate osteogenesis around implants and bone-implant contact. The Col/HA multilayer covalent-immobilized TC may reduce aseptic loosening of implant.
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