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Updated: Feb 10, 2026

Synthesis and Characterization of Amphiphilic Gold Nanoparticles
Published on: July 2, 2019
Facially amphiphilic polyionene biocidal polymers derived from lithocholic acid
Mitra S Ganewatta1,2, Md Anisur Rahman1, Louis Mercado1
1Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC 29208, USA.
Abstract:
Bacterial infections have become a global issue that requires urgent attention, particularly regarding to emergence of multidrug resistant bacteria. We developed quaternary amine-containing antimicrobial poly(bile acid)s that contain a hydrophobic core of lithocholic acid in the main-chain. Interestingly, by choosing appropriate monomers, these cationic polymers can form core-shell micelles. These polymers exhibited biocidal activity against both Gram-positive and Gram-negative bacterial species. It is demonstrated that the micelles can deliver hydrophobic antibiotics that functionally have dual antimicrobial activities. Cytotoxicity assays against HeLa cells showed dosage-dependent toxicity for polymers with longer linkers.
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