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Updated: Feb 10, 2026

Direct and Indirect Culture Methods for Studying Biodegradable Implant Materials In Vitro
Published on: April 15, 2022
In vitro biodegradation testing of Mg-alloy EZK400 and manufacturing of implant prototypes using PM (powder
M Wolff1, M Luczak1, J G Schaper1
1Helmholtz-Zentrum Geesthacht GmbH, Centre for Materials and Coastal Research, Institute of Materials Research, Max-Planck Str. 1, 21502 Geesthacht, Germany.
Abstract:
The study is focussing towards Metal Injection Moulding (MIM) of Mg-alloys for biomedical implant applications. Especially the influence of the sintering processing necessary for the consolidation of the finished part is in focus of this study. In doing so, the chosen high strength EZK400 Mg-alloy powder material was sintered using different sintering support bottom plate materials to evaluate the possibility of iron impurity pick up during sintering. It can be shown that iron pick up took place from the steel bottom plate into the specimen. Despite the fact that a separating boron nitrite (BN) barrier layer was used and the Mg-Fe phase diagram is not predicting any significant solubility to each other. As a result of this study a new bottom plate material not harming the sintering and the biodegradation performance of the as sintered material, namely a carbon plate material, was found.
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