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Related Experiment Video

Updated: Feb 10, 2026

Author Spotlight: Exploring Neural Correlates of Defensive Behaviors in Fear Learning and Extinction
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Behavioral interventions to eliminate fear responses.

Jingli Yue1, Le Shi1,2, Xiao Lin1,3

  • 1Peking University Sixth Hospital, Peking University Institute of Mental Health, Key of Mental Health, Ministry of Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, 100191, China.

Science China. Life Sciences
|May 11, 2018
PubMed
Summary

This review explores how to manipulate fear memory, crucial for anxiety disorders like PTSD. It highlights sleep

Keywords:
extinctionfear memoryhumanreconsolidationsleep manipulation

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Area of Science:

  • Neuroscience
  • Psychology
  • Sleep Science

Background:

  • Fear memory is central to anxiety-related disorders, notably posttraumatic stress disorder (PTSD).
  • Current PTSD treatments like exposure therapy aim to form extinction memories but often face challenges with fear recurrence.
  • Novel strategies are needed to enhance fear memory elimination or extinction memory consolidation.

Purpose of the Study:

  • To review research on manipulating fear memory through extinction and reconsolidation processes.
  • To discuss the role of sleep in regulating fear memory and extinction.
  • To summarize identified neural mechanisms and suggest future clinical applications.

Main Methods:

  • Literature review of studies targeting fear memory manipulation via extinction and reconsolidation.
  • Analysis of research investigating the influence of sleep on fear memory processes.
  • Synthesis of neural mechanisms underlying these memory manipulations in human studies.

Main Results:

  • Extinction and reconsolidation are key targets for manipulating fear memory.
  • Sleep plays an active role in regulating memory, including fear memory.
  • Neural mechanisms for these manipulations are increasingly understood through human studies.

Conclusions:

  • Targeting extinction and reconsolidation, potentially enhanced by sleep, offers promising avenues for treating fear-based disorders.
  • Further research is needed to translate these findings into effective clinical interventions for PTSD.
  • Understanding the neural underpinnings is crucial for developing better therapeutic strategies.