Related Experiment Video For acantholytic
Updated: Feb 10, 2026

Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
Morphologic mimicry: acantholytic squamous cell carcinoma in nondermal locations-a literature review
Mustafa Mohammad1, Rebecca Wilcox1
1The University of Vermont Medical Center/The Robert Larner, M.D. College of Medicine at The University of Vermont, Burlington, Vermont.
Abstract:
Acantholytic squamous cell carcinoma (acantholytic SCC) is a variant of SCC in which acantholysis develops owing to the loss of desmosomal adhesion proteins. This loss of cell-cell adhesion leads to morphologic changes that have the potential to mimic other tumor types, such as angiosarcoma or signet ring cell adenocarcinoma. Acantholytic SCC characteristically occurs in sun-exposed skin of elderly patients; however, it can occur in nondermal locations. We present a review of the literature describing cases of nondermal acantholytic SCC.
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