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Fast magnetic resonance fingerprinting for dynamic contrast-enhanced studies in mice

Yuning Gu1, Charlie Y Wang1, Christian E Anderson1

  • 1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio.

Magnetic Resonance in Medicine
|May 11, 2018
PubMed
Abstract

Insights

This study developed a fast Magnetic Resonance Fingerprinting (MRF) method for simultaneous T1 and T2 mapping in dynamic contrast-enhanced MRI (DCE-MRI) studies in mice, achieving 2-minute temporal resolution.

Area of Science:

  • Biomedical Imaging
  • Magnetic Resonance Imaging
  • Preclinical Research

Background:

  • Dynamic contrast-enhanced MRI (DCE-MRI) is crucial for preclinical tumor studies.
  • Accurate T1 and T2 mapping is essential for quantitative analysis in DCE-MRI.
  • Current methods can be time-consuming, limiting dynamic assessment.

Purpose of the Study:

  • To develop a rapid Magnetic Resonance Fingerprinting (MRF) technique for simultaneous T1 and T2 quantification.
  • To enable high temporal resolution mapping in DCE-MRI studies of mouse models.
  • To improve the dynamic assessment of contrast agent distribution in preclinical research.

Main Methods:

  • Implemented MRF sequences using balanced SSFP and fast imaging with steady-state precession on a 7T preclinical scanner.
  • Utilized a zeroth-moment-compensated variable-density spiral trajectory for k-space acquisition.
  • Evaluated MRF accuracy in vitro and in vivo (mouse brain) with fully sampled and undersampled data.

Main Results:

  • MRF T1 and T2 measurements in phantoms showed excellent agreement with conventional methods.
  • Up to 8-fold undersampling with spiral encoding was achieved without compromising accuracy.
  • Simultaneous T1 and T2 mapping with 2-minute temporal resolution was demonstrated in DCE-MRI studies.

Conclusions:

  • Magnetic Resonance Fingerprinting offers a powerful tool for dynamic contrast agent quantification.
  • This method is suitable for preclinical tumor models using high-field MRI scanners.
  • The developed fast MRF technique enhances the capabilities of DCE-MRI in preclinical research.
Keywords:
MR fingerprintingdynamic contrast-enhanced MRIdysprosiumgadoliniummouse

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