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Presynaptic inhibition decreases when estrogen level rises.

M A Hoffman1, J R Doeringer2, M F Norcross1

  • 1Oregon State University, Corvallis, OR, USA.

Scandinavian Journal of Medicine & Science in Sports
|May 11, 2018
PubMed
Summary

Estrogen levels significantly impact skeletal muscle control in women, affecting presynaptic inhibition (PI) during ovulation. This hormonal influence may explain higher knee injury rates in females.

Keywords:
H-reflexanterior cruciate ligamentinhibitioninjurysex hormones

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Area of Science:

  • Neuroscience
  • Endocrinology
  • Sports Medicine

Background:

  • Estrogen is a key hormone influencing various physiological processes.
  • Understanding estrogen's role in neuromuscular control is crucial for injury prevention.
  • Previous research has not fully elucidated estrogen's impact on skeletal muscle excitability and inhibition.

Purpose of the Study:

  • To investigate the influence of estrogen on skeletal muscle control in women.
  • To compare motorneuron excitability (H:M ratio) and presynaptic inhibition (PI) between sexes across the menstrual cycle.
  • To explore the relationship between estrogen fluctuations and neuromuscular function.

Main Methods:

  • Measured estrogen serum concentrations and presynaptic inhibition (PI) in 12 women and 13 men.
  • Tested women at menses (low estrogen) and ovulation (high estrogen); men tested twice.
  • Analyzed H:M ratio for motorneuron excitability and PI for neuromuscular control.

Main Results:

  • No significant difference in H:M ratio between sexes at any time point.
  • Significant differences in the magnitude of estrogen change (∆EST) and PI change (∆PI) between sexes.
  • Women exhibited a significant rise in estrogen and changes in PI from menses to ovulation.

Conclusions:

  • Estrogen levels significantly influence presynaptic inhibition in skeletal muscle.
  • Fluctuations in estrogen, particularly the rise during ovulation, affect neuromuscular control in women.
  • This hormonal modulation may contribute to the higher incidence of noncontact knee injuries in females.