Peering into the HIV reservoir
Marcial García1,2, María J Buzón3, José M Benito1,2
1Instituto de Investigación Sanitaria-Fundación Jiménez Díaz, Universidad Autónoma de Madrid (IIS-FJD, UAM), Madrid, Spain.
Reviews in Medical Virology
|May 11, 2018
Summary
Understanding the human immunodeficiency virus (HIV) reservoir is key to developing new therapies. Research into cellular HIV reservoirs beyond CD4 T-cells may reveal novel strategies for HIV eradication and functional cure.
Area of Science:
- Virology
- Immunology
- Infectious Diseases
Background:
- The persistent human immunodeficiency virus (HIV) reservoir is the primary barrier to HIV eradication.
- Current therapeutic strategies have limited success in eliminating the HIV reservoir.
Purpose of the Study:
- To enhance understanding of the mechanisms behind HIV reservoir establishment and maintenance.
- To identify novel therapeutic targets for purging the latent HIV reservoir.
- To explore cellular HIV reservoirs beyond resting memory CD4 T-cells.
Main Methods:
- Review of existing literature on HIV reservoir dynamics.
- Analysis of recently described cellular HIV reservoirs.
- Investigation of mechanisms maintaining viral persistence.
Main Results:
- The establishment and maintenance of the HIV reservoir are complex processes.
- Resting memory CD4 T-cells are a significant component of the HIV reservoir.
- Other cellular compartments also play crucial roles in HIV persistence.
Conclusions:
- Deeper knowledge of HIV reservoir mechanisms is essential for designing effective eradication strategies.
- Investigating non-CD4 T-cell reservoirs may offer new avenues for therapeutic intervention.
- Targeting specific cellular HIV reservoirs could lead to a functional cure or eradication.
Keywords:
HIV reservoirT follicular helper cellsmyeloid-derived cellsresting memory CD4 T cellsstem cell-like memory T cellsMore Related Videos
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