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Resveratrol inhibits glioma cell growth via targeting LRIG1

Lianfang Liu1, Yonghua Zhang, Kai Zhu

  • 1Department of Oncology, Zhangjiagang Hospital of Traditional Chinese Medicine affiliated to Nanjing University of Chinese Medicine, Jiangsu 215600, China.

Journal of B.U.ON. : Official Journal of the Balkan Union of Oncology
|May 11, 2018
PubMed
Abstract

Insights

Resveratrol boosts leucine repeat immunoglobulin-like protein 1 (LRIG1) in glioma cells, inhibiting growth and promoting apoptosis. This highlights LRIG1 as a potential target for glioma treatment.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Oncology

Background:

  • Glioma is a primary brain tumor with limited treatment options.
  • Resveratrol, a natural polyphenol, exhibits anti-cancer properties.
  • Leucine repeat immunoglobulin-like protein 1 (LRIG1) is implicated in cell growth regulation.

Purpose of the Study:

  • To investigate resveratrol's effect on LRIG1 expression in U251 glioma cells.
  • To determine the relationship between LRIG1 and glioma cell proliferation and apoptosis.
  • To identify potential new therapeutic targets for glioma treatment.

Main Methods:

  • U251 glioma cells were treated with resveratrol.
  • Reverse transcription-polymerase chain reaction (RT-PCR) and Western blotting assessed LRIG1 and related factor expression.
  • Loss-of-function assays, MTT assays, and flow cytometry evaluated cell proliferation and apoptosis.

Main Results:

  • Resveratrol upregulated LRIG1 mRNA and protein expression in U251 cells.
  • Resveratrol treatment decreased cell proliferation and increased apoptosis.
  • LRIG1 small interference reversed resveratrol's effects on proliferation and apoptosis.

Conclusions:

  • Resveratrol inhibits glioma growth and proliferation by upregulating LRIG1.
  • LRIG1 acts as an anti-glioma growth factor.
  • LRIG1 represents a novel biological target for resveratrol in glioma therapy.

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