[Research progress about different levels of cognitive recession using resting state functional connectivity network
Yanan Liu1, Yuanyuan Chen1, Miao Sha1
1Tianjin University, School of Precision Instrument and Opto-Electronics Engineering, Tianjin 300072, P.R.China.
Summary
Resting-state functional magnetic resonance imaging (fMRI) reveals changes in brain networks associated with cognitive decline. This review examines functional connectivity in normal aging, mild cognitive impairment, and Alzheimer's disease.
Area of Science:
- Neuroscience
- Medical Imaging
- Cognitive Science
Context:
- Cognitive decline, including memory and attention deficits, impacts quality of life.
- Neurodegenerative diseases and normal brain aging share common pathways of decline.
- The precise mechanisms underlying cognitive decline remain a significant research challenge.
Purpose:
- To review recent research on brain functional connectivity using resting-state fMRI.
- To compare findings across different levels of cognitive function: normal aging, mild cognitive impairment (MCI), and Alzheimer's disease (AD).
- To elucidate changes in brain functional networks associated with cognitive decline.
Summary:
- Resting-state fMRI is sensitive to cognitive function changes.
- Functional connectivity alterations are observed in normal aging, MCI, and AD.
- This review synthesizes current understanding of network changes in cognitive decline.
Impact:
- Provides a basis for detecting normal brain aging.
- Offers insights for identifying and understanding clinical neurodegenerative diseases.
- Highlights the utility of fMRI in assessing cognitive health and disease progression.
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