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Expression and clinical relations of protein tyrosine phosphatase receptor type S in esophageal squamous cell

Guoliang Zhang1, Xinyang Liu2, Jingjing Wu3

  • 1Department of Thoracic Surgery, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.

Histology and Histopathology
|May 11, 2018
PubMed

Insights

Reduced expression of Protein tyrosine phosphatase receptor S (PTPRS) in esophageal squamous cell carcinoma (ESCC) correlates with advanced disease and poor survival. PTPRS loss indicates a more aggressive clinical course in ESCC patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Protein tyrosine phosphatase receptor S (PTPRS) is a tumor suppressor gene located at chromosome 19p13.3.
  • PTPRS is frequently inactivated in various cancers via deletions or epigenetic modifications.

Purpose of the Study:

  • To investigate PTPRS expression levels in esophageal squamous cell carcinoma (ESCC).
  • To analyze the clinicopathological and prognostic significance of PTPRS in ESCC.

Main Methods:

  • Immunohistochemistry was used to examine PTPRS expression in 205 ESCC tissues and paired normal esophageal mucosa.
  • Tissue Microarrays (TMAs) were utilized for protein analysis.
  • Statistical analyses included Kaplan-Meier survival and Cox regression.

Main Results:

  • PTPRS was significantly down-regulated in ESCC tissues compared to normal tissues (P=0.006).
  • Reduced PTPRS expression correlated with advanced TNM stage, deeper invasion, lymph node metastasis, and poor tumor differentiation (P<0.001).
  • Low PTPRS expression was linked to significantly poorer patient survival (P=0.002) and identified as an independent predictor of overall survival (HR=1.573, P=0.049).

Conclusions:

  • Loss of PTPRS expression is associated with aggressive clinical features and shorter survival in ESCC patients.
  • PTPRS deficiency may predict a more aggressive clinical course and increased recurrence.
  • PTPRS functions as a tumor suppressor, playing a crucial role in ESCC progression and metastasis.

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