Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Predicting Reaction Outcomes02:24

Predicting Reaction Outcomes

11.0K
Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...
11.0K
Decreasing Function01:27

Decreasing Function

309
A decreasing function describes a relationship where the output consistently declines as the input increases. This means that for any two input values, if one is greater than the other, the corresponding output is smaller. Mathematically, a function f is decreasing on an interval I if for every x1 < x2​ in I, f (x1) > f (x2). This type of behavior is visually identified on a graph that slopes downward from left to right.The nature of a function can be analyzed by calculating...
309
Decreased Body Temperature01:29

Decreased Body Temperature

1.1K
A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by...
1.1K
Decreased pulse rate01:14

Decreased pulse rate

918
Bradycardia is a medical condition in which the heart rate is slower than normal. It occurs when the heart's natural pacemaker, the sinus node, generates slower electrical impulses than the standard rhythm. In adults, bradycardia is diagnosed when the pulse rate falls below 60 beats per minute, indicating a deviation from the normal heart rate range.
There are specific risk factors that can elevate the likelihood of developing bradycardia. Advanced age is a significant factor, with...
918
Predicting Molecular Geometry02:27

Predicting Molecular Geometry

46.1K
VSEPR Theory for Determination of Electron Pair Geometries
46.1K
Outcomes of Glycolysis01:13

Outcomes of Glycolysis

107.6K
Nearly all the energy used by cells comes from the bonds that make up complex organic compounds. These organic compounds are broken down into simpler molecules, such as glucose. As a result, cells extract energy from glucose over many chemical reactions—a process called cellular respiration.
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
107.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Changes in SSM Assessed via 100 Hz-VCTE Are Associated With Acute HVPG-Response to i.v. Propranolol: A European Multicentre Study.

Liver international : official journal of the International Association for the Study of the Liver·2026
Same author

Delphi survey to explore core curriculum for training the next-generation of hepatologists<sup>☆</sup>.

JHEP reports : innovation in hepatology·2026
Same author

Reply to: "Are FIB-4 and liver stiffness measurement interchangeable for HCC risk stratification in MASLD?"

JHEP reports : innovation in hepatology·2026
Same author

Functional Liver Imaging Score (FLIS): A Prognostic Biomarker for Acute-on-Chronic Liver Failure and Liver-Related Mortality.

JHEP reports : innovation in hepatology·2026
Same author

Stage-Specific Drivers of Clinical Progression in Advanced Chronic Liver Disease.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association·2026
Same author

Characterization of liver disease regression in murine models of liver fibrosis and portal hypertension.

Scientific reports·2026

Related Experiment Video

Updated: Feb 10, 2026

The Use of Pharmacological-challenge fMRI in Pre-clinical Research: Application to the 5-HT System
11:27

The Use of Pharmacological-challenge fMRI in Pre-clinical Research: Application to the 5-HT System

Published on: April 25, 2012

15.9K

Pharmacological decrease of liver stiffness is pressure-related and predicts long-term clinical outcome.

Felix Piecha1, Mattias Mandorfer2, Teresa Peccerella1

  • 1Department of Medicine, Salem Medical Center and Center for Alcohol Research, University of Heidelberg , Heidelberg , Germany.

American Journal of Physiology. Gastrointestinal and Liver Physiology
|May 11, 2018
PubMed
Summary

Liver stiffness (LS) measurements are affected by hemodynamic changes. In patients with cirrhosis, a decrease in LS after propranolol treatment may predict better outcomes, independent of MELD scores.

Keywords:
hepatic hemodynamicshepatic venous pressure gradientportal hypertensiontransient elastography

More Related Videos

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia
11:06

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia

Published on: April 7, 2023

2.8K
Measurement of Liver Stiffness Using Atomic Force Microscopy Coupled with Polarization Microscopy
10:10

Measurement of Liver Stiffness Using Atomic Force Microscopy Coupled with Polarization Microscopy

Published on: July 20, 2022

4.6K

Related Experiment Videos

Last Updated: Feb 10, 2026

The Use of Pharmacological-challenge fMRI in Pre-clinical Research: Application to the 5-HT System
11:27

The Use of Pharmacological-challenge fMRI in Pre-clinical Research: Application to the 5-HT System

Published on: April 25, 2012

15.9K
Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia
11:06

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia

Published on: April 7, 2023

2.8K
Measurement of Liver Stiffness Using Atomic Force Microscopy Coupled with Polarization Microscopy
10:10

Measurement of Liver Stiffness Using Atomic Force Microscopy Coupled with Polarization Microscopy

Published on: July 20, 2022

4.6K

Area of Science:

  • Hepatology
  • Cardiovascular Physiology
  • Non-invasive Diagnostics

Background:

  • Liver stiffness (LS) assessed by transient elastography is a key non-invasive marker for liver fibrosis.
  • Hemodynamic factors, including arterial and portal pressures, significantly influence LS measurements.
  • Understanding these influences is crucial for accurate fibrosis assessment and patient management.

Purpose of the Study:

  • To investigate the impact of acute hemodynamic changes on LS in a rodent cirrhosis model.
  • To evaluate the relationship between LS changes, hemodynamic parameters, and clinical outcomes in cirrhotic patients treated with propranolol.

Main Methods:

  • Utilized a rodent model of cirrhosis to assess LS (µFibroscan) following pharmacological modulation of portal pressure (losartan, nitric oxide donors, propranolol).
  • Analyzed LS and hepatic venous pressure gradient (HVPG) changes in 38 cirrhotic patients treated with propranolol.
  • Correlated LS changes with hemodynamic parameters (MAP, PP, HVPG) and clinical outcomes (transplantation, death, MELD scores).

Main Results:

  • In the animal model, LS decrease correlated with reduced mean arterial pressure (MAP) and portal pressure (PP) after losartan or NO administration.
  • Propranolol acutely decreased heart rate but did not alter MAP, leading to stable LS in animals.
  • In humans, 66% of patients showed decreased LS after propranolol, correlating with HVPG but not with significant changes in transaminases or MELD.
  • Decreased LS on propranolol was associated with a lower risk of transplantation or death, irrespective of HVPG.

Conclusions:

  • Hemodynamic modulation of arterial and portal pressures significantly influences LS changes following pharmacological interventions.
  • In cirrhotic patients, a decrease in LS during propranolol therapy may serve as a predictive marker for improved clinical outcomes.
  • LS changes offer a potential additional follow-up tool for monitoring cirrhotic patients, independent of MELD scores.