Recommendations for Diagnosis and Management of Autoimmune Pancreatitis in Childhood: Consensus From INSPPIRE

Area of Science:

• Pediatric gastroenterology
• Immunology
• Pancreatology

Background:

• Autoimmune pancreatitis (AIP) is a complex immune-mediated pancreatic disorder.
• Pediatric AIP (P-AIP) is a rare manifestation of AIP in children.
• Previous work has characterized the distinct features of P-AIP.

Framework:

• A panel of pediatric gastroenterologists from the International Study Group of Pediatric Pancreatitis: In search for a cuRE (P-AIP) was convened.
• The panel engaged in discussions and voting on 15 proposed recommendation statements.
• Consensus required at least 80% agreement, achieved after three rounds of voting and statement revisions.

Implementation:

• Fifteen recommendation statements were generated by the expert panel.
• These statements aim to establish a standardized approach for P-AIP diagnosis.
• The recommendations also provide guidance for P-AIP management.

Implications:

• The developed statements represent the first set of P-AIP recommendations.
• They are intended to standardize the diagnostic and therapeutic strategies for P-AIP.
• These guidelines will facilitate uniform patient care and promote future research in P-AIP.