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Factors Influencing the Intestinal Microbiome During the First Year of Life

Petra Zimmermann1,2,3,4, Nigel Curtis1,2,3

  • 1From the Department of Paediatrics, The University of Melbourne, Parkville, Australia.

The Pediatric Infectious Disease Journal
|May 11, 2018
PubMed

Insights

The infant gut microbiome is shaped by various factors, influencing immune system development and long-term health risks like allergies. Understanding these early influences allows for potential health interventions.

Area of Science:

  • Immunology
  • Microbiology
  • Pediatrics

Background:

  • The intestinal microbiome is vital for immune system development and regulation.
  • Early life microbial composition impacts future health, including allergies and autoimmune diseases.

Purpose of the Study:

  • To review factors influencing the infant intestinal microbiome composition within the first year of life.
  • To highlight the connection between early microbiome establishment and health outcomes.

Main Methods:

  • Literature review of factors affecting the infant gut microbiome.
  • Analysis of influences such as birth location, delivery mode, feeding, and antibiotic use.

Main Results:

  • Numerous factors significantly shape the infant intestinal microbiome.
  • These factors include gestational age, delivery mode, feeding practices, hospitalization, and antibiotic/probiotic use.

Conclusions:

  • Early life factors critically establish the intestinal microbiome.
  • Understanding these influences offers opportunities for interventions to promote infant health and prevent adverse outcomes.

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