Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ion Channels01:19

Ion Channels

91.5K
The movement of ions like sodium, potassium, and calcium into and out of the cell is essential to maintain the electrochemical gradient in living cells. The ion channels—a class of membrane transport proteins—help maintain this ionic gradient for the smooth functioning of physiological activities such as maintaining cell size and volume, conducting nerve impulses, and gas and nutrient exchange.
Ion channels are specialized integral membrane proteins on the plasma membrane that allow...
91.5K
Pore Size Distribution01:23

Pore Size Distribution

492
In concrete, the pore size distribution significantly influences the material's properties. Capillary pores, markedly larger than gel pores, form a vast network within partially hydrated cement paste, reducing the concrete's strength and increasing its permeability. This heightened permeability leads to a greater risk of damage from environmental factors like freeze-thaw cycles and chemical attacks, with the extent of vulnerability also being tied to the water-to-cement ratio.
Adequate...
492
Pore Transport and Ion-Pair Transport01:17

Pore Transport and Ion-Pair Transport

1.3K
Pore transport and ion-pair formation are critical mechanisms for the absorption and distribution of drugs in the body.
Pore transport, also known as convective transport, is a process where small molecules like urea, water, and sugars rapidly cross cell membranes as though there were channels or pores in the membrane. Although direct microscopic evidence is limited  but the concept of pores or channels is widely accepted based on physiological evidence. Despite the lack of direct...
1.3K
Channel Rhodopsins01:11

Channel Rhodopsins

3.3K
Most organisms use photoreceptors to sense and respond to light. Examples of photoreceptors include bacteriorhodopsins and bacteriophytochromes in some bacteria, phytochromes in plants, and rhodopsins in the photoreceptor cells of the vertebral retina. The light-sensitive property of these receptors is because of the bound chromophores, such as bilin in the phytochromes and retinal in the rhodopsins.
Rhodopsins belong to the family of cell surface proteins called G-protein coupled receptors,...
3.3K
Non-gated Ion Channels01:24

Non-gated Ion Channels

8.3K
Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism....
8.3K
Channels of Non-Verbal Communication01:28

Channels of Non-Verbal Communication

453
Non-verbal communication plays a critical role in human interaction, influencing how individuals perceive emotions and psychological states. It operates through four primary channels: facial expressions, eye contact, body language, and touch. These non-verbal cues help convey meaning beyond spoken language and are often culturally influenced.Facial Expressions and Emotional RecognitionFacial expressions are among the most powerful and universal forms of non-verbal communication. Research has...
453

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Retraction Note: Amelioration of intracerebroventricular streptozotocin-induced cognitive dysfunction by Ocimum sanctum L. through the modulation of inflammation and GLP-1 levels.

Metabolic brain disease·2026
Same author

Evaluation of mixed response in tumor size and survival in patients with rare cancers treated with dual checkpoint inhibitor therapy (DART SWOG S1609).

Journal for immunotherapy of cancer·2026
Same author

Liquid liquid phase separation of the intrinsically disordered protein JPT2 compartmentalizes components of NAADP-evoked Ca<sup>2+</sup> signaling.

bioRxiv : the preprint server for biology·2026
Same author

Direct measurements of luminal Ca2+ with endo-lysosomal GFP-aequorin reveal functional IP3 receptors.

The Journal of cell biology·2025
Same author

Salivary protein biomarkers for the diagnosis of oral squamous cell carcinoma: a systematic review and meta-analysis.

Diagnosis (Berlin, Germany)·2025
Same author

Neuroprotective Effects of a 3-Amino Quinazoline Derivative via Keap1-Nrf2 Pathway Activation in an ICV-STZ-Induced Rat Model of Sporadic Alzheimer's Disease.

ACS chemical neuroscience·2025
Same journal

Cell mechanosensing at focal adhesions: Emerging insights from phase separation.

Biochimica et biophysica acta. Molecular cell research·2026
Same journal

Mupirocin-mediated downregulation of claudin-14 enhances chemosensitivity in human colorectal cancer cells.

Biochimica et biophysica acta. Molecular cell research·2026
Same journal

Focadhesin interacts with SALL4 to regulate EGFR signaling and oncogenesis in non-small cell lung cancer.

Biochimica et biophysica acta. Molecular cell research·2026
Same journal

Extracellular matrix stiffness primes the NLRP3-Inflammasome by promoting NLRP3 gene expression via FAK/mTOR/nuclear-actin/SREBP signalling in vascular smooth muscle cells.

Biochimica et biophysica acta. Molecular cell research·2026
Same journal

A putative role for Mrx3 and Fmp10 in regulating yeast mitochondrial acyl-CoA thioesters.

Biochimica et biophysica acta. Molecular cell research·2026
Same journal

Narirutin inhibits inflammation and oxidative stress in osteoarthritis via suppressing AKT/NF-κB signaling.

Biochimica et biophysica acta. Molecular cell research·2026
See all related articles

Related Experiment Video

Updated: Feb 10, 2026

Fabrication and Visualization of Capillary Bridges in Slit Pore Geometry
11:20

Fabrication and Visualization of Capillary Bridges in Slit Pore Geometry

Published on: January 9, 2014

9.3K

Two-pore channels and disease.

Sandip Patel1, Bethan S Kilpatrick1

  • 1Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom.

Biochimica Et Biophysica Acta. Molecular Cell Research
|May 11, 2018
PubMed
Summary
This summary is machine-generated.

Two-pore channels (TPCs) regulate calcium (Ca2+) release from cellular organelles. Disrupting TPCs can induce or reverse various disease states, highlighting their therapeutic potential.

Keywords:
Ca(2+)LysosomesNAADPTPCN1TPCN2

More Related Videos

Creating Transient Cell Membrane Pores Using a Standard Inkjet Printer
07:07

Creating Transient Cell Membrane Pores Using a Standard Inkjet Printer

Published on: March 16, 2012

39.4K
Confocal Microscopy to Measure Three Modes of Fusion Pore Dynamics in Adrenal Chromaffin Cells
12:30

Confocal Microscopy to Measure Three Modes of Fusion Pore Dynamics in Adrenal Chromaffin Cells

Published on: March 16, 2022

2.6K

Related Experiment Videos

Last Updated: Feb 10, 2026

Fabrication and Visualization of Capillary Bridges in Slit Pore Geometry
11:20

Fabrication and Visualization of Capillary Bridges in Slit Pore Geometry

Published on: January 9, 2014

9.3K
Creating Transient Cell Membrane Pores Using a Standard Inkjet Printer
07:07

Creating Transient Cell Membrane Pores Using a Standard Inkjet Printer

Published on: March 16, 2012

39.4K
Confocal Microscopy to Measure Three Modes of Fusion Pore Dynamics in Adrenal Chromaffin Cells
12:30

Confocal Microscopy to Measure Three Modes of Fusion Pore Dynamics in Adrenal Chromaffin Cells

Published on: March 16, 2022

2.6K

Area of Science:

  • Cellular Biology
  • Ion Channel Physiology
  • Disease Mechanisms

Background:

  • Two-pore channels (TPCs) are endo-lysosomal ion channels permeable to calcium (Ca2+).
  • TPCs release Ca2+ from acidic organelles, crucial for cellular signaling.
  • NAADP is a key second messenger regulating TPC activity.

Purpose of the Study:

  • To review emerging evidence linking TPCs to various human diseases.
  • To discuss the role of TPCs in modulating Ca2+ homeostasis in disease.
  • To identify TPCs as potential therapeutic targets.

Main Methods:

  • Literature review of studies investigating TPCs in disease models.
  • Analysis of chemical and molecular manipulations affecting TPC function.
  • Examination of TPC involvement in diverse pathological conditions.

Main Results:

  • Perturbation of TPCs can induce or reverse disease phenotypes.
  • TPCs are implicated in Parkinson's disease, NAFLD, Ebola infection, cancer, cardiac dysfunction, and diabetes.
  • Modulating TPC activity offers a potential strategy for disease intervention.

Conclusions:

  • TPCs play a significant role in the pathophysiology of multiple diseases.
  • Targeting TPCs presents a promising avenue for novel therapeutic development.
  • Further research and drug development targeting TPCs are warranted.