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Updated: Feb 10, 2026

Chemical Amputation and Regeneration of the Pharynx in the Planarian Schmidtea mediterranea
Published on: March 26, 2018
In silico analysis of Schmidtea mediterranea TIR domain-containing proteins
Landry Laure Tsoumtsa1, Seynabou Sougoufara1, Cedric Torre1
1MEPHI, IRD, APHM, Institut Hospitalier Universitaire Méditerranée-Infection, 19-21 Bd Jean Moulin, 13385, Marseille Cedex 05, France.
Abstract:
While genetic evidence points towards an absence of Toll-Like Receptors (TLRs) in Platyhelminthes, the Toll/IL-1 Receptor (TIR)-domains that drive the assembly of signalling complexes downstream TLR are present in these organisms. Here, we undertook the characterisation of the repertoire of TIR-domain containing proteins in Schmidtea mediterranea in order to gain valuable information on TLR evolution in metazoan. We report the presence of twenty proteins containing between one and two TIR domains. In addition, our phylogenetic-based reconstruction approach identified Smed-SARM and Smed-MyD88 as conserved TLR adaptors.
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