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Polysaccharides-based multiparticulated interpolyelectrolyte complexes for controlled benznidazole release.

Mónica C García1, Rubén H Manzo1, Alvaro Jimenez-Kairuz1

  • 1Departamento de Ciencias Farmacéuticas, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina; Unidad de Investigación y Desarrollo en Tecnología Farmacéutica - UNITEFA (CONICET-UNC), Argentina.

International Journal of Pharmaceutics
|May 11, 2018
PubMed
Summary
This summary is machine-generated.

Novel chitosan-alginic acid interpolyelectrolyte complexes (IPECs) offer controlled release of benznidazole (BZ) for Chagas disease treatment. These drug delivery systems show promise for reducing BZ side effects and administration frequency.

Keywords:
Alginic acidBenznidazoleChitosanDrug deliveryPolyelectrolyte complexes

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Area of Science:

  • Biomaterials Science
  • Pharmaceutical Sciences
  • Drug Delivery

Background:

  • Chagas disease pharmacotherapy relies on benznidazole (BZ), but its efficacy and safety are limited by side effects.
  • Polysaccharide-based delivery systems, including interpolyelectrolyte complexes (IPECs), offer potential for controlled drug release and improved therapeutic outcomes.

Purpose of the Study:

  • To develop and characterize novel multiparticulated benznidazole-loaded interpolyelectrolyte complexes (IPECs) using chitosan and alginic acid.
  • To investigate the physicochemical and pharmacotechnical properties of these BZ-loaded IPECs for Chagas disease treatment.

Main Methods:

  • IPECs were prepared using the casting solvent method followed by wet granulation.
  • Physicochemical characterization included assessment of ionic interactions, drug distribution, flow properties, and mucoadhesion.
  • In vitro drug release studies were conducted in different media to evaluate release modulation based on fluid uptake.

Main Results:

  • The developed IPECs demonstrated ionic interactions between chitosan and alginic acid.
  • Benznidazole was uniformly distributed within the IPECs, which exhibited suitable flow properties for capsule formulation.
  • The multiparticulated IPECs showed mucoadhesion and modulated benznidazole release based on the release medium and fluid uptake.

Conclusions:

  • The novel chitosan-alginic acid IPECs show promising properties for the development of improved Chagas disease pharmacotherapy.
  • These drug delivery systems have the potential to mitigate benznidazole's adverse effects and/or reduce administration frequency.