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Bioinspired bone therapies using naringin: applications and advances.
Pedro Lavrador1, Vitor M Gaspar1, João F Mano1
1Department of Chemistry, CICECO - Aveiro Institute of Materials, University of Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal.
Drug Discovery Today
|May 11, 2018
Summary
Naringin, a natural compound, shows promise for treating bone diseases like osteoporosis. Its properties support bone health and regeneration, making it valuable for tissue engineering.
Area of Science:
- Biomaterials Science
- Pharmacology
- Regenerative Medicine
Background:
- Natural compounds offer therapeutic potential for chronic bone diseases.
- Naringin, a flavanone glycoside, exhibits diverse beneficial effects on bone tissues.
- Existing treatments for bone disorders have limitations, driving the search for novel therapeutics.
Purpose of the Study:
- To review current applications of naringin in treating bone disorders, including osteoporosis and osteoarthritis.
- To explore naringin's potential in promoting stem cell differentiation for bone regeneration.
- To critically assess the clinical translation of naringin and its use with biomaterials.
Main Methods:
- Literature review of preclinical and clinical studies on naringin and bone health.
- Analysis of naringin's molecular mechanisms related to osteogenesis and bone resorption.
- Examination of recent advancements in biomaterial-based delivery systems for naringin.
Main Results:
- Naringin demonstrates pro-osteogenic, antiresorptive, and antiadipogenic properties.
- Naringin shows potential in enhancing stem cell differentiation towards osteoblasts.
- Biomaterial strategies can improve naringin's bioavailability and therapeutic efficacy.
Conclusions:
- Naringin is a promising natural compound for managing bone disorders and promoting bone regeneration.
- Further research and clinical translation are needed to fully realize naringin's therapeutic potential.
- Naringin, particularly when combined with advanced biomaterials, holds significant promise for bone tissue engineering and regenerative medicine.
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