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Visualization of Gut Microbiota-host Interactions via Fluorescence In Situ Hybridization, Lectin Staining, and Imaging
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Functional Aspects of Fish Mucosal Lectins-Interaction with Non-Self
Monica Fengsrud Brinchmann1, Deepti Manjari Patel2, Nevil Pinto3,4
1Faculty of Biosciences and Aquaculture, Nord University, 8049 Bodø, Norway. monica.f.brinchmann@nord.no.
Molecules (Basel, Switzerland)
|May 12, 2018
Summary
Teleost mucosal lectins are crucial for fish immunity, exhibiting agglutination, growth inhibition, and direct killing activities against pathogens. Further research could unlock their potential as novel antibiotics and antiparasitics.
Area of Science:
- Immunology
- Marine Biology
- Zoology
Background:
- Mucosal surfaces are vital for animal defense against pathogens.
- Host molecules on mucosal surfaces interact with non-self entities to prevent infection.
- Both inhibition and stimulation of uptake mechanisms can impede pathogen invasion.
Purpose of the Study:
- To review the current knowledge on teleost mucosal lectins.
- To focus on the interaction of these lectins with non-self entities.
- To highlight their roles in agglutination, growth inhibition, opsonisation, cell adhesion, and direct killing.
Main Methods:
- Literature review of existing research on teleost mucosal lectins.
- Synthesis of data on lectin activities including agglutination, growth inhibition, opsonisation, cell adhesion, and direct killing.
- Analysis of the importance of lectins in fish innate immunity.
Main Results:
- Teleost mucosal lectins demonstrate diverse activities against non-self.
- These activities include pathogen agglutination, growth inhibition, opsonisation, cell adhesion, and direct killing.
- Lectins play a significant role in the innate immune system of fish.
Conclusions:
- Teleost mucosal lectins are key components of the innate immune system in fish.
- Understanding these lectins is essential for comprehending fish immunity.
- Lectins hold potential for developing new antibiotic and antiparasitic treatments for veterinary and human pathogens.
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