Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Sustainable Development01:43

Sustainable Development

15.2K
As the human population continues to grow and use resources, we must be mindful of our planet’s natural limits. Sustainable development provides a pathway to maintain and improve human life now while also ensuring that future generations will have the resources that they need. The long-term success of sustainability efforts rests on understanding the interplay between human actions and ecological systems.
15.2K
Drugs Affecting Neurotransmitter Release or Uptake01:21

Drugs Affecting Neurotransmitter Release or Uptake

1.6K
Certain drugs can affect how neurotransmitters called catecholamines, are released or taken back up in the adrenergic neuron. They can have different effects on the body's sympathetic transmission. Reserpine, a natural compound found in the Rauwolfia shrub, blocks a transporter called vesicular monoamine transporter (VMAT), which leads to a buildup of catecholamines in the cell and reduces sympathetic transmission. Another drug called guanethidine works in multiple ways, including blocking...
1.6K
Drug Delivery: Overview01:16

Drug Delivery: Overview

903
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
903
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

1.9K
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
1.9K
Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

1.8K
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
1.8K
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

837
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
837

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

p53-miR-34a feedback in lung fibroblasts regulates antifibrotic effects of CSP7, nintedanib, and pirfenidone.

American journal of physiology. Lung cellular and molecular physiology·2025
Same author

Comment on Hermeling et al. Nano-Dry-Melting: A Novel Technology for Manufacturing of Pharmaceutical Amorphous Solid Dispersions. <i>Pharmaceutics</i> 2022, <i>14</i>, 2145.

Pharmaceutics·2025
Same author

Correction to "Inhaled JAK Inhibitor GDC-0214 Nanoaggregate Powder Exhibits Improved Pharmacokinetic Profile in Rats Compared to the Micronized Form: Benefits of Thin Film Freezing".

Molecular pharmaceutics·2024
Same author

Characterization of mRNA Lipid Nanoparticles by Electron Density Mapping Reconstruction: X-ray Scattering with Density from Solution Scattering (DENSS) Algorithm.

Pharmaceutical research·2024
Same author

Inhaled JAK Inhibitor GDC-0214 Nanoaggregate Powder Exhibits Improved Pharmacokinetic Profile in Rats Compared to the Micronized Form: Benefits of Thin Film Freezing.

Molecular pharmaceutics·2024
Same author

Pre-Processing a Polymer Blend into a Polymer Alloy by KinetiSol Enables Increased Ivacaftor Amorphous Solid Dispersion Drug Loading and Dissolution.

Biomedicines·2023

Related Experiment Video

Updated: Feb 10, 2026

Manufacture and Drug Delivery Applications of Silk Nanoparticles
09:03

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

16.6K

Sustained Release Drug Delivery Applications of Polyurethanes.

Michael B Lowinger1,2, Stephanie E Barrett3, Feng Zhang4

  • 1College of Pharmacy, The University of Texas at Austin, 2409 University Avenue, Austin, TX 78712, USA. michael.lowinger@utexas.edu.

Pharmaceutics
|May 12, 2018
PubMed
Summary

Polyurethanes offer versatile applications in modified drug delivery systems. This review highlights their use in sustained release formulations, examining factors influencing drug release kinetics.

Keywords:
drug deliveryisocyanatelong-actingpolyurethanesustained release

More Related Videos

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

8.9K
Slow-release Drug Delivery through Elvax 40W to the Rat Retina: Implications for the Treatment of Chronic Conditions
07:49

Slow-release Drug Delivery through Elvax 40W to the Rat Retina: Implications for the Treatment of Chronic Conditions

Published on: September 17, 2014

12.0K

Related Experiment Videos

Last Updated: Feb 10, 2026

Manufacture and Drug Delivery Applications of Silk Nanoparticles
09:03

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

16.6K
Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

8.9K
Slow-release Drug Delivery through Elvax 40W to the Rat Retina: Implications for the Treatment of Chronic Conditions
07:49

Slow-release Drug Delivery through Elvax 40W to the Rat Retina: Implications for the Treatment of Chronic Conditions

Published on: September 17, 2014

12.0K

Area of Science:

  • Materials Science
  • Pharmaceutical Sciences
  • Biomedical Engineering

Background:

  • Polyurethanes have broad industrial applications.
  • Drug delivery research using polyurethanes has seen recent resurgence.
  • Understanding polyurethane chemistry is key for drug delivery.

Purpose of the Study:

  • To review polyurethane applications in modified-release drug delivery.
  • To discuss factors affecting drug release from polyurethane systems.
  • To highlight recent advancements and assessment methods.

Main Methods:

  • Literature review of polyurethane-based drug delivery systems.
  • Analysis of polyurethane chemistry and drug release mechanisms.
  • Examination of factors influencing drug release kinetics.

Main Results:

  • Polyurethanes are effective in developing modified-release drug delivery systems.
  • Hydrophilic swelling and pore formers significantly modulate drug release.
  • Drug properties and mechanical characteristics impact formulation performance.

Conclusions:

  • Polyurethanes are a promising material for advanced drug delivery.
  • Further research into material properties and formulation design is warranted.
  • Optimizing polyurethane-based systems can enhance therapeutic outcomes.