Related Experiment Video
Updated: Feb 10, 2026

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Multimorbidity in Older Adults With Cardiovascular Disease
Daniel E Forman1, Mathew S Maurer2, Cynthia Boyd3
1Department of Medicine, Section of Geriatric Cardiology, Veterans Affairs Geriatric Research Education, and Clinical Center, University of Pittsburgh, Pittsburgh, Pennsylvania.
Insights
Older adults often have cardiovascular disease (CVD) alongside multiple other health conditions (multimorbidity). Current care focuses on single diseases, missing the complexity of treating older patients with concurrent conditions.
Area of Science:
- Gerontology
- Cardiology
- Public Health
Background:
- Multimorbidity, the presence of multiple chronic conditions, is common in older adults.
- Cardiovascular disease (CVD) frequently co-occurs with other conditions in this demographic.
- Current healthcare models primarily address single diseases, often failing to manage complex patient needs.
Purpose of the Study:
- To review emerging concepts of cardiovascular disease (CVD) in the context of multimorbidity.
- To provide recommendations for integrating multimorbidity into clinical decision-making for older patients.
- To identify knowledge gaps and research priorities for optimizing care.
Main Methods:
- Literature review of emerging concepts in CVD and multimorbidity.
- Analysis of current clinical practice and research paradigms.
- Synthesis of recommendations for clinical integration and future research.
Main Results:
- Older adults with CVD often present with complex multimorbidity.
- Single-disease focused care is inadequate for managing these complex patients.
- There is a need to incorporate multimorbidity into clinical decision-making and research.
Conclusions:
- Optimizing care for older adults with CVD requires addressing multimorbidity.
- Future research should prioritize understanding and managing concurrent conditions.
- Clinical practice must evolve to embrace the complexity of multimorbidity in older populations.
Abstract:
Multimorbidity occurs in adults of all ages, but the number and complexity of comorbid conditions commonly increase with advancing age such that cardiovascular disease (CVD) in older adults typically occurs in a context of multimorbidity. Current clinical practice and research mainly target single disease-specific care that does not embrace the complexities imposed by concurrent conditions. In this paper, emerging concepts regarding CVD in combination with multimorbidity are reviewed, including recommendations for incorporating multimorbidity into clinical decision making, critical knowledge gaps, and research priorities to optimize care of complex older patients.
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