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Discovery of bicyclo[3,3,1]non-2-ene as a novel skeleton for HIF-1 inhibitors

Hiroki Ueda1, Atsushi Yoshimori2, Hiroyuki Nakamura3

  • 1Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, Nagatsuta-cho, Midori-ku, Yokohama 226-8503, Japan; School of Life Science and Technology, Tokyo Institute of Technology, Nagatsuta-cho, Midori-ku, Yokohama 226-8503, Japan.

Bioorganic & Medicinal Chemistry
|May 12, 2018
PubMed

Keywords:
Hypoxia inducible factor (HIF)-1αInhibitorProteasomal degradationTranscriptional activity

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