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Related Experiment Video

Updated: Feb 10, 2026

Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging
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Remote Left Ventricular Hemodynamic Monitoring Using a Novel Intracardiac Sensor.

Thomas Mondritzki1,2, Philip Boehme3,2, Jason White4

  • 1From the Bayer AG, Wuppertal, Germany (T.M., P.B., J.H., J.V., P.K., S.W., P.S., E.B., W.D., J.H., H.T.) thomas.mondritzki@bayer.com.

Circulation. Cardiovascular Interventions
|May 12, 2018
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Summary
This summary is machine-generated.

A new implantable wireless pressure sensor can monitor heart failure (HF) decompensation. This technology helps identify at-risk patients early, guiding treatment and reducing hospitalizations.

Keywords:
dogsheart failuremodels, animaltelemetryvasopressins

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Area of Science:

  • Biomedical Engineering
  • Cardiovascular Research
  • Medical Devices

Background:

  • Heart failure (HF) is a leading cause of hospitalization for individuals over 65.
  • High mortality and readmission rates persist despite current HF therapies.
  • Early identification of patients at risk for readmission is crucial for timely intervention.

Purpose of the Study:

  • To validate a novel batteryless, implantable left ventricular (LV) microelectromechanical system (MEMS) for assessing LV performance.
  • To evaluate the potential of this device as a telemetric tool for early detection of HF decompensation.

Main Methods:

  • A miniaturized implantable wireless pressure sensor was adapted for LV apex implantation in a canine HF model.
  • LV-microelectromechanical system sensor measurements were compared against invasive left heart catheterization data.
  • Device sensitivity was assessed during pharmacological challenges (dobutamine, vasopressin).

Main Results:

  • The wireless pressure sensor demonstrated comparable sensitivity to invasive methods.
  • No adverse events or device-related reactions were observed over 35 days post-implantation.
  • The device successfully monitored LV hemodynamics in a preclinical HF model.

Conclusions:

  • The LV-microelectromechanical system is a promising new telemetric tool for HF management.
  • Early identification of HF decompensation risk can be achieved with this device.
  • This technology may help guide HF treatment and reduce hospitalizations.