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Related Concept Videos

Clinical Trials01:16

Clinical Trials

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Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
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Clinical Trials: Overview01:11

Clinical Trials: Overview

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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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Statistical Software for Data Analysis and Clinical Trials01:12

Statistical Software for Data Analysis and Clinical Trials

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Statistical software is pivotal in data analysis and clinical trials by providing tools to analyze data, draw conclusions, and make predictions. These software packages range from simple data management applications to complex analytical platforms, supporting various statistical tests, models, and simulation techniques. Their significance lies in their ability to handle vast amounts of data with precision and efficiency, enabling researchers to validate hypotheses, identify trends, and make...
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Psychology as a Science01:13

Psychology as a Science

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Psychology, as a scientific discipline, aims to understand the mind and behavior through rigorous and systematic methods. The foundation of psychological research is evidence-based, relying heavily on the scientific method to derive and validate knowledge. This structured approach ensures that findings are reliable, valid, and applicable to broader contexts.
The scientific method in psychology involves six critical steps: making observations, formulating hypotheses, conducting tests, analyzing...
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Trial and Error and Algorithm01:12

Trial and Error and Algorithm

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A problem-solving strategy is a plan of action used to find a solution. Different strategies have distinct action plans. Trial and error involves trying different solutions until one works. For instance, to fix a broken printer, you might check ink levels, ensure the paper tray isn't jammed, and verify the printer's connection to your laptop. This method can be time-consuming but is commonly used. Thomas Edison, for example, used trial and error to find a suitable filament for the light...
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Energy Basics02:27

Energy Basics

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Chemical reactions, such as those that occur when you light a match, involve changes in energy as well as matter.
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In Silico Clinical Trials for Cardiovascular Disease
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PCSK9: From Basic Science Discoveries to Clinical Trials.

Michael D Shapiro1, Hagai Tavori1, Sergio Fazio2

  • 1From the Center for Preventive Cardiology, Knight Cardiovascular Institute, Oregon Health & Science University, Portland.

Circulation Research
|May 12, 2018
PubMed
Summary
This summary is machine-generated.

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is crucial for managing atherosclerotic cardiovascular disease. Genetic insights into PCSK9 have rapidly led to effective medical therapies, transforming treatment strategies.

Keywords:
dyslipidemiashyperlipoproteinemia type IIlipid metabolismlipoproteinsreceptors, LDL

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Area of Science:

  • Cardiovascular Science
  • Molecular Biology
  • Pharmacology

Background:

  • Proprotein convertase subtilisin/kexin type 9 (PCSK9) was largely unknown 15 years ago.
  • PCSK9 plays a significant role in lipoprotein metabolism and atherosclerotic cardiovascular disease (ASCVD).

Purpose of the Study:

  • To review the scientific understanding of PCSK9's role in ASCVD.
  • To discuss the rapid translation of PCSK9 insights into effective medical therapies.
  • To examine the clinical impact of PCSK9-inhibiting therapies.

Main Methods:

  • Review of major scientific literature on PCSK9.
  • Analysis of genetic insights leading to drug discovery.
  • Evaluation of clinical data for PCSK9 inhibitors.

Main Results:

  • PCSK9 is a key target for managing ASCVD.
  • Genetic discoveries have accelerated the development of novel therapeutics.
  • PCSK9 inhibition has shown significant clinical impact.

Conclusions:

  • The PCSK9 field has advanced rapidly, demonstrating successful translation from basic science to clinical application.
  • Targeting PCSK9 represents a paradigm shift in cardiovascular disease prevention and treatment.
  • Further research and clinical application of PCSK9 inhibitors are ongoing.