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A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
Published on: January 5, 2017
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Microvessel density in head and neck squamous cell carcinoma
Tomasz Szafarowski1, Janusz Sierdzinski2, Miroslaw J Szczepanski3,4
1Department of Otolaryngology, Faculty of Medicine and Dentistry, Czerniakowski Hospital, Medical University of Warsaw, 19/25 Stępińska Str., 00-739, Warsaw, Poland.
Summary
Microvessel density (MVD) is elevated in head and neck squamous cell carcinoma (HNSCC). However, MVD/CD34 levels unexpectedly decreased in advanced HNSCC tumors, suggesting potential underestimation of vascularity.
Area of Science:
- Oncology
- Pathology
- Biomarker Research
Background:
- Microvessel density (MVD) quantifies tumor angiogenesis, a key factor in cancer progression.
- Vascular endothelial markers like CD34 and CD105 are commonly used for MVD assessment.
- Head and neck squamous cell carcinoma (HNSCC) is a significant clinical challenge requiring better prognostic markers.
Purpose of the Study:
- To assess MVD in HNSCC patients using CD34 and CD105.
- To evaluate the predictive value of MVD for HNSCC outcomes.
- To compare MVD in HNSCC with non-malignant and dysplastic tissues.
Main Methods:
- Immunohistochemistry (IHC) on tissue microarrays (TMA) from 49 HNSCC patients, 11 dysplasia patients, and 12 controls.
- Quantification of MVD using CD34 and CD105 expression.
- Analysis of clinicopathological factors and 5-year patient survival.
Main Results:
- MVD/CD34 and MVD/CD105 were significantly higher in HNSCC compared to control and dysplastic tissues (p<0.01).
- Unexpectedly, MVD/CD34 was significantly lower in advanced T3-T4 tumors compared to early T1-T2 tumors (p=0.01).
Conclusions:
- HNSCC exhibits significantly higher MVD than surrounding non-malignant tissues.
- MVD/CD34 did not correlate with tumor invasiveness (T stage) in HNSCC.
- Current MVD assessment methods using CD34/CD105 on TMA may underestimate HNSCC tumor vascularity.
Keywords:
CD105CD34Head and neck squamous cell carcinomaLarynx dysplasiaMicrovessel densityTissue microarraysMore Related Videos
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