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Prognostic Value of MicroRNAs in Coronary Artery Diseases: A Meta-Analysis

Ji Suk Kim1,2, Kyoungjune Pak1,3, Tae Sik Goh1,4

  • 1BEER, Busan Society of Evidence-based Mdicine and Research, Busan, Korea.

Yonsei Medical Journal
|May 12, 2018
PubMed
Abstract

Insights

This study confirms microRNA 133a has prognostic value in coronary artery disease (CAD) patients, associating its high expression with increased mortality. It corrects errors in a previous meta-analysis, providing accurate miRNA prognostic data for CAD.

Area of Science:

  • Biomedical research
  • Cardiovascular medicine
  • Molecular biology

Background:

  • Coronary artery diseases (CADs) are a leading global cause of mortality.
  • MicroRNAs (miRNAs) are increasingly recognized as potential biomarkers for cardiovascular prognosis.
  • Previous meta-analyses on miRNA prognostic value in CAD have contained significant errors.

Purpose of the Study:

  • To conduct an updated systematic review and meta-analysis of the prognostic value of altered miRNAs in patients with CAD.
  • To correct inaccuracies identified in a prior meta-analysis concerning miRNA and CAD prognosis.
  • To provide reliable data on the association between specific miRNAs and clinical outcomes in CAD.

Main Methods:

  • Systematic literature search of MEDLINE and EMBASE databases up to May 2017.
  • Inclusion of studies reporting survival data or major adverse cardiac events (MACEs) in CAD patients with miRNA analysis.
  • Independent data extraction by two reviewers and pooled hazard ratio (HR) calculation using a fixed-effect model.

Main Results:

  • Eight studies were included after reviewing 515 articles.
  • High expression of miRNA 133a was significantly associated with increased mortality (pooled HR, 2.35; 95% CI, 1.56-3.55).
  • Elevated levels of several other miRNAs (e.g., 208b, 126, 197) were linked to higher mortality, while others (e.g., 208b, 499-5p, 134) were associated with MACEs.

Conclusions:

  • MicroRNA 133a demonstrates significant prognostic value in coronary artery disease patients, particularly regarding mortality.
  • This updated meta-analysis provides corrected and accurate information on miRNA prognostic implications in CAD.
  • The findings underscore the potential of specific miRNAs as biomarkers for risk stratification in CAD.
Keywords:
Coronary artery diseasemeta-analysismicroRNAprognosis

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