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Presence of the adenovirus E1A-like activity in preimplantation stage mouse embryos
H Suemori1, S Hashimoto, N Nakatsuji
1Division of Developmental Biology, Meiji Institute of Health Science, Odawara, Japan.
Molecular and Cellular Biology
|August 1, 1988
Abstract:
The presence of the adenovirus E1A-like activity in embryonal carcinoma stem cells has been reported. We now show that preimplantation stage mouse embryonic cells allow transcription of the E1A-dependent E2A gene when infected with E1A-deleted mutant dl312, indicating the presence of the E1A-like activity in morulae and blastocysts. Moreover, such activity seems to decrease or disappear at about the time of implantation.