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Related Concept Videos

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The heart, an organ critical to survival, gets nourishment not from the blood it pumps but from a separate circulation system known as coronary circulation. This is the shortest circulation in the body and is responsible for supplying the heart with the nutrients it needs to function effectively.
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Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
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Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
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Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
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Nursing Assessment:Nursing management of acute coronary syndrome (ACS) involves taking the patient's history, focusing on primary complaints such as chest pain, dyspnea, and excessive sweating (diaphoresis), as well as other symptoms like back or jaw pain, nausea, vomiting, palpitations, dizziness, and fatigue. The nurse also reviews the patient's history of cardiac events, risk factors such as hypertension, diabetes, smoking, family history, and current medications.In the objective assessment,...
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Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
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Related Experiment Video

Updated: Feb 10, 2026

Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery
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Irisin in Coronary Bypass Surgery.

Suna Aydin1,2, Zekiye Catak3, Mehmet Nesimi Eren4

  • 1Cardiovascular Surgery Department, Elazig Research and Education Hospital, Health Science University, 23119 Elazig, Turkey.

Cardiovascular & Hematological Disorders Drug Targets
|May 12, 2018
PubMed
Summary

Irisin levels correlate with lactate during coronary bypass surgery, potentially serving as a marker for hypothermia and myocardial injury. Monitoring irisin alongside lactate may improve surgical patient management.

Keywords:
Coronary bypass surgerieshypothermiairisinlactatemyocardium injurypituitary gland.

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Area of Science:

  • Cardiology
  • Biochemistry
  • Surgical Monitoring

Background:

  • Coronary bypass surgery involves cardiopulmonary bypass and patient cooling.
  • Irisin is involved in thermoregulation and heat release.

Purpose of the Study:

  • To investigate irisin concentrations during coronary artery bypass surgery.
  • To explore the correlation between irisin, lactate, and myocardial injury markers.

Main Methods:

  • Blood samples were collected from 105 bypass patients and 23 controls at multiple time points.
  • Irisin, CK-MB, TnT, BNP, and lactate levels were measured using ELISA and assay kits.

Main Results:

  • Irisin and lactate levels increased during cooling and decreased during rewarming, correlating with each other.
  • Changes in CK-MB, TnT, and BNP were similar.

Conclusions:

  • Irisin may serve as a useful marker for hypothermia during coronary bypass surgery.
  • Measuring irisin alongside lactate could aid in monitoring myocardial injury and surgical outcomes.