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Bone mineral density and vitamin K status in children with celiac disease: Is there a relation?

Burcu Volkan1, Ali Fettah2, Ali İşlek3

  • 1Department of Pediatric Gastroenterology, Erzurum Regional Training and Research Hospital, Erzurum, Turkey.

The Turkish Journal of Gastroenterology : the Official Journal of Turkish Society of Gastroenterology
|May 12, 2018
PubMed

Insights

Children with celiac disease (CD) have lower bone mineral density (BMD) compared to healthy peers. Vitamin D and K2 levels did not differ, suggesting other factors influence bone health in pediatric CD.

Area of Science:

  • Pediatric Endocrinology
  • Gastroenterology
  • Bone Metabolism

Background:

  • Celiac disease (CD) is an autoimmune disorder affecting the small intestine.
  • Children with CD are at risk for nutritional deficiencies impacting bone health.
  • Osteoporosis is a potential complication in pediatric celiac disease.

Purpose of the Study:

  • To investigate bone mineral density (BMD) in children diagnosed with celiac disease.
  • To evaluate the association between vitamin K levels and osteoporosis in pediatric celiac disease.
  • To compare BMD and vitamin levels between children with CD and healthy controls.

Main Methods:

  • Prospective study including children with CD and age/sex-matched healthy controls.
  • Bone mineral density (BMD) measurement using Z scores.
  • Assay of serum markers including anti-tissue transglutaminase IgA, vitamin D, vitamin K2, calcium, phosphate, and parathormone.

Main Results:

  • Children with CD exhibited significantly lower mean BMD Z scores compared to controls (-1.23±1.07 vs. -0.35±1.04, p=0.001).
  • No significant differences in serum vitamin D and K2 levels were observed between the celiac and control groups.
  • BMD showed a positive correlation with vitamin D (r=0.198, p=0.001) and a negative correlation with parathormone (PTH) (r=-0.397, p=0.002).

Conclusions:

  • Pediatric celiac disease is associated with reduced bone mineral density.
  • Vitamin D and K2 levels do not appear to differ between children with CD and healthy controls.
  • Further research is warranted to elucidate the role and impact of vitamin K on bone health in pediatric celiac disease.
Abstract

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