Adaptive optimal input design and parametric estimation of nonlinear dynamical systems: application to neuronal...

Many physical models of biological processes including neural systems are characterized by parametric nonlinear dynamical relations between driving inputs, internal states, and measured outputs of the process. Fitting such models using experimental data (data assimilation) is a challenging task since the physical process often operates in a noisy, possibly non-stationary environment; moreover, conducting multiple experiments under controlled and repeatable conditions can be impractical, time consuming or costly. The accuracy of model identification, therefore, is dictated principally by the quality and dynamic richness of collected data over single or few experimental sessions. Accordingly, it is highly desirable to design efficient experiments that, by exciting the physical process with smart inputs, yields fast convergence and increased accuracy of the model.

We herein introduce an adaptive framework in which optimal input design is integrated with square root cubature Kalman filters (OID-SCKF) to develop an online estimation procedure that first, converges significantly quicker, thereby permitting model fitting over shorter time windows, and second, enhances model accuracy when only few process outputs are accessible. The methodology is demonstrated on common nonlinear models and on a four-area neural mass model with noisy and limited measurements. Estimation quality (speed and accuracy) is benchmarked against high-performance SCKF-based methods that commonly employ dynamically rich informed inputs for accurate model identification.

For all the tested models, simulated single-trial and ensemble averages showed that OID-SCKF exhibited (i) faster convergence of parameter estimates and (ii) lower dependence on inter-trial noise variability with gains up to around 1000 ms in speed and 81% increase in variability for the neural mass models. In terms of accuracy, OID-SCKF estimation was superior, and exhibited considerably less variability across experiments, in identifying model parameters of (a) systems with challenging model inversion dynamics and (b) systems with fewer measurable outputs that directly relate to the underlying processes.

Fast and accurate identification therefore carries particular promise for modeling of transient (short-lived) neuronal network dynamics using a spatially under-sampled set of noisy measurements, as is commonly encountered in neural engineering applications.