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Updated: Feb 10, 2026

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
Published on: November 3, 2010
Association of IL-6 polymorphisms with chronic obstructive pulmonary disease risk: meta-analysis of genetic
Liyan Dou1, Baiquan Yu2, Kaiyu Han2
1Department of Cardiology, the Fourth Affiliated Hospital of Harbin Medical University, Heilongjiang, 150081, China.
Aim:
IL-6 might play an important role in the mechanism of chronic obstructive pulmonary disease (COPD). This study assessed the relationship of rs1800796 and rs1800797 of IL-6 with COPD.
Materials & Methods:
We conducted meta-analysis and gene expression analysis using published datasets to examine the associations between IL-6 SNPs and COPD.
Results:
rs1800796 was significantly associated with COPD, yielding a pooled odds ratio of 0.52 (95% CI: 0.33-0.84; p = 0.007), and showed cis-expression quantitative trait locus associations (p = 0.02148). Differential gene expression analysis found that IL-6 was upregulated in COPD cases compared with controls. The associations of rs1800797 with COPD were not significant.
Conclusion:
The findings showed that rs1800796 was associated with COPD in Europeans and might affect COPD risk through disturbing IL-6 gene expression.
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