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Specific Eph receptor-cytoplasmic effector signaling mediated by SAM-SAM domain interactions

Yue Wang1, Yuan Shang2, Jianchao Li2

  • 1Shenzhen Key Laboratory for Neuronal Structural Biology, Biomedical Research Institute, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen, China.

Elife
|May 12, 2018
PubMed
Summary

Researchers uncovered a specific pattern in how Eph receptor tyrosine kinases (RTKs) bind to effector proteins via SAM domains. This finding explains how Eph receptors transmit diverse signals and sheds light on disease-related mutations.

Keywords:
Eph receptor tyrosine kinaseSAM domainSAM-SAM interactionephrinforward signalinghumanmolecular biophysicsstructural biology

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