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Updated: Feb 10, 2026

Measurement of mRNA Decay Rates in Saccharomyces cerevisiae Using rpb1-1 Strains
Published on: December 13, 2014
Viral manipulation of host mRNA decay
Liang Guo1,2,3, Irina Vlasova-St Louis1, Paul R Bohjanen1,4,2,3
1Department of Medicine, Division of Infectious Diseases & International Medicine, Program in Infection & Immunity, University of Minnesota, Minneapolis, MN 55455, USA.
Abstract:
Viruses alter host-cell gene expression at many biochemical levels, such as transcription, translation, mRNA splicing and mRNA decay in order to create a cellular environment suitable for viral replication. In this review, we discuss mechanisms by which viruses manipulate host-gene expression at the level of mRNA decay in order to enable the virus to evade host antiviral responses to allow viral survival and replication. We discuss different cellular RNA decay pathways, including the deadenylation-dependent mRNA decay pathway, and various strategies that viruses exploit to manipulate these pathways in order to create a virus-friendly cellular environment.
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