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Updated: Feb 10, 2026

Gyroid Nickel Nanostructures from Diblock Copolymer Supramolecules
Published on: April 28, 2014
Nickel-Catalyzed Coupling of Arylzinc Halides with Thioesters
Paul H Gehrtz1, Prasad Kathe1, Ivana Fleischer1
1Institute of Organic Chemistry, Faculty of Mathematics and Natural Sciences, Eberhard-Karls University Tübingen, Auf der Morgenstelle 18, 72076, Tübingen, Germany.
Abstract:
The Pd-catalyzed Fukuyama reaction of thioesters with organozinc reagents is a mild, functional-group-tolerant method for acylation chemistry. Its Ni-catalyzed variant might be a sustainable alternative to expensive catalytic Pd sources. We investigated the reaction of S-ethyl thioesters with aryl zinc halides with hetero- and homotopic Ni precatalysts and several ligands. The results show that both homo- and heterotopic species may contribute to catalysis. The substrate scope using an operationally homogeneous defined Ni complex was established. Acyl radicals are postulated as short-lived intermediates.
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