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Sampling Human Indigenous Saliva Peptidome Using a Lollipop-Like Ultrafiltration Probe: Simplify and Enhance Peptide Detection for Clinical Mass Spectrometry
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Saliva in the "Omics" era: A promising tool in paediatrics

Eftychia Pappa1, Eleni Kousvelari2, Heleni Vastardis3

  • 1Department of Operative Dentistry, School of Dentistry, National and Kapodistrian University of Athens, Athens, Greece.

Oral Diseases
|May 12, 2018
PubMed

Insights

Saliva diagnostics offer a noninvasive method for diagnosing diseases in children. This review highlights the "omic" spectrum of salivary biomarkers for pediatric health and disease, paving the way for future advancements.

Area of Science:

  • Pediatric Diagnostics
  • Biomarker Discovery
  • Omics Technologies

Background:

  • Saliva is an ideal noninvasive diagnostic medium for infants and children.
  • Unique salivary biomarker profiles aid in diagnosing various diseases and conditions.
  • Omics-based discoveries (genomics, proteomics, etc.) provide powerful diagnostic information.

Purpose of the Study:

  • To review current and future applications of saliva diagnostics in pediatrics.
  • To highlight pediatric studies across the "omic" spectrum.
  • To identify emerging frontiers in salivary diagnostics research.

Main Methods:

  • Review of existing literature on salivary diagnostics in children.
  • Analysis of studies utilizing "omic" approaches in pediatric saliva samples.
  • Identification of key biomarkers and diagnostic applications.

Main Results:

  • Saliva diagnostics are effective for detecting caries, periodontitis, and systemic conditions in children.
  • Omics technologies reveal comprehensive diagnostic insights from saliva.
  • Applications extend to metabolic diseases, cognitive function, stress, and immune responses.

Conclusions:

  • Saliva diagnostics represent a powerful, noninvasive tool for pediatric health assessment.
  • Continued research across the "omic" spectrum will expand salivary diagnostics' utility.
  • Emerging frontiers promise significant advancements in early disease detection and monitoring.

Keywords:
childrenomicsoral healthpaediatricssaliva diagnostics

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