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Updated: Feb 10, 2026

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
Published on: April 1, 2019
Higher than expected clozapine serum level and clozapine/norclozapine ratio due to CYP450 gene polymorphisms
Dorgival Caetano1,2, Irina Piatkov2
1Blacktown Mental Health Service, WSLHD, Blacktown, NSW, 2148, Australia.
Aims:
We investigated a case of the unexpectedly high clozapine/norclozapine serum levels in a non-smoker, female patient.
Method:
The RFLP genotype method was used for the loss-of-function CYP450 gene polymorphisms detection.
Results:
The genotype revealed the presence of CYP2D6*41/*41, rs28371725, NM_000106.5:c.985+39G>A and CYP1A2*1/*1D rs35694136, NM_000761.4:c.-1635delT.
Conclusion:
An appropriate clozapine serum level is required for both optimization of clinical response and avoidance of troublesome, or even life-threatening side effects. Although not the only factor, genetic polymorphisms responsible for the metabolism of clozapine play an important role towards such goals. Pharmacogenetic tests can guide dose adjustment in order to obtain an optimum serum level, which can lead to a better therapeutic response and minimization of harmful side effects.
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