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Definition of reference ranges for β-isomerized carboxy-terminal telopeptide collagen type I for children and

Veronica C P de Melo1, Paulo R S Ferreira1, Lucelia O Ricardi1

  • 1Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.

Journal of Pediatric Endocrinology & Metabolism : JPEM
|May 12, 2018
PubMed

Insights

This study establishes reference ranges for beta-isomerized carboxy-terminal telopeptides collagen type I (β-CTX), a bone resorption marker, in children and adolescents. These findings aid in diagnosing bone diseases in pediatric populations.

Area of Science:

  • Pediatric Endocrinology
  • Bone Metabolism Research
  • Clinical Diagnostics

Background:

  • Bone metabolism is complex and frequently disrupted in pediatric bone diseases.
  • Existing pediatric reference intervals for bone markers are limited by small study sizes and methodological inconsistencies.
  • Accurate pediatric reference values for bone resorption markers are needed.

Purpose of the Study:

  • To determine reference values for beta-isomerized carboxy-terminal telopeptides collagen type I (β-CTX) in children and adolescents.
  • To establish reliable pediatric reference ranges for a key marker of bone resorption.
  • To support clinical evaluation of pediatric bone health.

Main Methods:

  • Blood samples were collected from 246 pediatric patients.
  • Beta-isomerized carboxy-terminal telopeptides collagen type I (β-CTX) levels were measured.
  • An electrochemiluminescence immunoassay (ECLI) was utilized for quantification.

Main Results:

  • Reference ranges for β-CTX concentration were established using the 2.5th and 97.5th percentiles.
  • Age-specific reference values for β-CTX were determined for pediatric populations.
  • The study provides novel reference data for a significant bone resorption marker.

Conclusions:

  • Proposed reference ranges for β-CTX in children and adolescents are presented.
  • These reference values can assist in evaluating conditions like osteosarcoma and anorexia.
  • The findings contribute to improved diagnostic capabilities for pediatric bone disorders.
Abstract

Keywords:
adolescentsbone metabolismchildrenβ-isomerized carboxy-terminal telopeptides collagen type I

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